{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:09:08Z","timestamp":1788296948309,"version":"build-2803163510"},"reference-count":89,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008398","name":"Villum Fonden","doi-asserted-by":"publisher","award":["25867"],"award-info":[{"award-number":["25867"]}],"id":[{"id":"10.13039\/100008398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,7,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A novel enantioselective (8+3) cycloaddition between donor\u2013acceptor cyclopropanes and heptafulvenoids catalysed by a chiral bifunctional Br\u00f8nsted base is described. Importantly, the reaction, which leverages an anionic activation strategy, is divergent from prototypical Lewis\u2010acid activation protocols. A series of cyclopropylketones react with tropones affording the desired (8+3) cycloadducts in high yield and enantiomeric excess. For barbiturate substituted heptafulvenes, the (8+3) cycloaddition with cyclopropylketones proceeds in good yield, excellent diastereoselectivity and high enantiomeric excess. The experimental work is supported by DFT calculations, which indicate that the bifunctional organocatalyst activates both the donor\u2013acceptor cyclopropane and tropone; the reaction proceeds in a step\u2010wise manner with the ring\u2010closure being the stereodetermining step.<\/jats:p>","DOI":"10.1002\/anie.202206096","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T16:50:40Z","timestamp":1652806240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Enantioselective (8+3) Cycloadditions by Activation of Donor\u2013Acceptor Cyclopropanes Employing Chiral Br\u00f8nsted Base Catalysis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-5554","authenticated-orcid":false,"given":"David A.","family":"McLeod","sequence":"first","affiliation":[{"name":"Department of Chemistry Aarhus University  8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-4410","authenticated-orcid":false,"given":"Mathias Kirk","family":"Th\u00f8gersen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aarhus University  8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4724-4294","authenticated-orcid":false,"given":"Casper Larsen","family":"Barl\u00f8se","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aarhus University  8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Louise","family":"Skipper","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aarhus University  8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlaitz Basabe","family":"Obreg\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aarhus University  8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3482-6236","authenticated-orcid":false,"given":"Karl Anker","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Aarhus University  8000 Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"For a summary of activation modes 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