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The current method enables the efficient preparation of highly functionalized \u03b4\u2010hydroxyesters bearing 1,4\u2010nonadjacent stereocenters in good yields with high levels of diastereoselectivity and excellent enantioselectivity under mild reaction conditions. The full complement of the four stereoisomers of hydroalkylation products could be readily accessed by orthogonal permutations of two chiral metal catalysts. The current work highlights the power of relay catalysis for the stereodivergent construction of 1,4\u2010nonadjacent stereocenters that were otherwise inaccessible.<\/jats:p>","DOI":"10.1002\/anie.202206517","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T11:08:56Z","timestamp":1656414536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Stereodivergent Construction of 1,4\u2010Nonadjacent Stereocenters via Hydroalkylation of Racemic Allylic Alcohols Enabled by Copper\/Ruthenium Relay Catalysis"],"prefix":"10.1002","volume":"61","author":[{"given":"Xin","family":"Chang","sequence":"first","affiliation":[{"name":"College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds &amp; Materials Ministry of Education Wuhan University Wuhan 430072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds &amp; 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