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The functionalization of unactivated \u03b2\u2010C\u2212H bonds in such carbonyl compounds is less well investigated and developing a general method for their \u03b2\u2010C\u2212H arylation remains challenging. Herein we report a method that uses cooperative nickel and photoredox catalysis for the formal \u03b2\u2010C\u2212H arylation of aldehydes and ketones with (hetero)aryl bromides. The method features mild conditions, remarkable scope and wide functional group tolerance. Importantly, the introduced synthetic strategy also allows the \u03b2\u2010alkenylation, \u03b2\u2010alkynylation and \u03b2\u2010acylation of aldehydes under similar conditions. Mechanistic studies revealed that this transformation proceeds through a single electron oxidation\/Ni\u2010mediated coupling\/reductive elimination cascade.<\/jats:p>","DOI":"10.1002\/anie.202206533","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T07:40:02Z","timestamp":1654242002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Formal \u03b2\u2010C\u2212H Arylation of Aldehydes and Ketones by Cooperative Nickel and Photoredox Catalysis"],"prefix":"10.1002","volume":"61","author":[{"given":"Kun","family":"Liu","sequence":"first","affiliation":[{"name":"Organisch-Chemisches Institut Westf\u00e4lische Wilhelms-Universit\u00e4t  Corrensstra\u00dfe 40 48149 M\u00fcnster 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