{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:51:10Z","timestamp":1777049470577,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,8,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The combination of covalent and non\u2010covalent synthesis is omnipresent in nature and potentially enables access to new materials. Yet, the fundamental principles that govern such a synthesis are barely understood. Here, we demonstrate how even simple reaction mixtures behave surprisingly complex when covalent reactions are coupled to self\u2010assembly processes. Specifically, we study the reaction behavior of a system in which the in situ formation of discotic benzene\u20101,3,5\u2010tricarboxamide (BTA) monomers is linked to an intertwined non\u2010covalent reaction network including self\u2010assembly into helical BTA polymers. This system shows an unexpected phase\u2010separation behavior in which an interplay of reactant\/product concentrations, side\u2010products and solvent purity determines the system composition. We envision that these insights can bring us one step closer to how to design the synthesis of systems in a combined covalent\/non\u2010covalent fashion.<\/jats:p>","DOI":"10.1002\/anie.202206729","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T19:45:33Z","timestamp":1656445533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["In situ Synthesis of Supramolecular Polymers: Finding the Right Conditions when Combining Covalent and Non\u2010Covalent Synthesis"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3613-576X","authenticated-orcid":false,"given":"Tobias","family":"Schnitzer","sequence":"first","affiliation":[{"name":"Institute of Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  P. O. Box 513 5600 MB Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-3967","authenticated-orcid":false,"given":"S. A. H.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Institute of Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  P. O. Box 513 5600 MB Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-7215","authenticated-orcid":false,"given":"Mathijs F. J.","family":"Mabesoone","sequence":"additional","affiliation":[{"name":"Institute of Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  P. O. Box 513 5600 MB Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-8892","authenticated-orcid":false,"given":"Ghislaine","family":"Vantomme","sequence":"additional","affiliation":[{"name":"Institute of Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  P. O. Box 513 5600 MB Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4126-7492","authenticated-orcid":false,"given":"E. W.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Institute of Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry Eindhoven University of Technology  P. O. 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