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Recently developed hollow multishelled structures (HoMSs) offers structural advantages, such as easily modifiable surfaces and mutually influenced shells. Herein, we report a novel pH\u2010responsive antimicrobial carrier having hierarchical shells as multilevel responsive bodies using polyethylene glycol (PEG) as a gated regulator. The interaction between PEG\u2010functionalized shells endows them with a pH\u2010responsive switch and rate\u2010regulator capability. These features are present in the form of rapid release of molecules wrapped in the outer shell, and controlled diffusion of antimicrobials stored in the inner shell by electrostatic interaction, resulting in a long\u2010lasting mildew resistance for up to 71\u2005days. The versatility of the hierarchical interactions of HoMSs will inspire the design of promising smart drug carriers.<\/jats:p>","DOI":"10.1002\/anie.202206807","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T08:46:08Z","timestamp":1655887568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["PEG\u2010Functionalized Hollow Multishelled Structures with On\u2010Off Switch and Rate\u2010Regulation for Controllable Antimicrobial Release"],"prefix":"10.1002","volume":"61","author":[{"given":"Decai","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering Institute of Process Engineering  1 North 2nd Street, Zhongguancun Beijing 100190 P. R. 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