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For instance, their selective reduction is problematic if both more nucleophilic and more electrophilic groups are present in the starting material. Here, we address this problem with a simple and mild protocol using bench\u2010stable reagents at ambient temperatures. This platform is able to tolerate a diverse range of functionality, leaving ketones, esters, nitro\u2010groups, olefins, nitriles and amides untouched. A combination of experimental and computational mechanistic experiments demonstrate that this reaction proceeds via hidden borane catalysis with small quantities of in situ generated BH<jats:sub>3<\/jats:sub>playing a key role in the exquisite selectivity that is observed.<\/jats:p>","DOI":"10.1002\/anie.202207647","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T12:58:34Z","timestamp":1662037114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mild and Chemoselective Carboxylic Acid Reduction Promoted by Borane Catalysis"],"prefix":"10.1002","volume":"61","author":[{"given":"Danijela","family":"Lunic","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-0824","authenticated-orcid":false,"given":"Nil","family":"Sanosa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro de Investigaci\u00f3n en S\u00edntesis Qu\u00edmica (CISQ) Universidad de La Rioja Madre de Dios 53 26006 Logro\u00f1o Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-9660","authenticated-orcid":false,"given":"Ignacio","family":"Funes\u2010Ardoiz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Centro de Investigaci\u00f3n en S\u00edntesis Qu\u00edmica (CISQ) Universidad de La Rioja Madre de Dios 53 26006 Logro\u00f1o Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-5674","authenticated-orcid":false,"given":"Christopher J.","family":"Teskey","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry RWTH Aachen University Landoltweg 1 52074 Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201787"},{"key":"e_1_2_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201201787"},{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201301088"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.1c00140"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c00302"},{"key":"e_1_2_3_5_1","volume-title":"Reductions by the Alumino- and Borohydrides in Organic Synthesis","author":"Seyden-Penne J.","year":"1997"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo9520699"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)00480-8"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)00734-0"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198902181"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19891010231"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0406918"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00038a044"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b03108"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b00900"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b00406"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB00485H"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC08841A"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b01038"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07062"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.9b04606"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202114482"},{"key":"e_1_2_3_20_2","doi-asserted-by":"crossref","first-page":"e202114482","DOI":"10.1002\/ange.202114482","volume":"134","year":"2022","journal-title":"Angew. 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