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In this chemistry, an unprecedented intermolecular nucleopalladation of diarylalkynes through the highly selective sequential double insertion of isocyanide was achieved for the first time. The practicality of this method was further demonstrated by the construction of various bioactive molecules and important structural motifs, with potential applications in materials science and biochemistry. In addition, density functional theory calculations (DFT) elucidated an interesting \u201cPd walk\u201d during the cyclization process.<\/jats:p>","DOI":"10.1002\/anie.202208203","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T02:06:13Z","timestamp":1658541973000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Divergent Synthesis of Fused Tetracyclic Heterocycles from Diarylalkynes Enabled by the Selective Insertion of Isocyanide"],"prefix":"10.1002","volume":"61","author":[{"given":"Meng","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 510641 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixue","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Institute of Computational Chemistry College of Chemistry Beijing University of Chemical Technology  Beijing 10019 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushan","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 510641 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanfeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology  Guangzhou 510641 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Institute of 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