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However, methods to prepare diaryl difluoromethanes are scarce, especially methods starting from abundant aryl halides. We report the Pd\u2010catalyzed aryldifluoromethylation of aryl halides with aryldifluoromethyl trimethylsilanes (TMSCF<jats:sub>2<\/jats:sub>Ar). The reaction occurs when the catalyst contains a simple, but unusual, dialkylaryl phosphine ligand that promotes transmetallation of the silane. Computational studies show that reductive elimination following transmetallation occurs with a low barrier, despite the fluorine atoms on the \u03b1\u2010carbon, due to coordination of the difluorobenzyl \u03c0\u2010system to palladium. The co\u2010development of a cobalt\u2010catalyzed synthesis of the silanes broadened the scope of the process including several applications to the synthesis biologically relevant diaryl difluoromethanes.<\/jats:p>","DOI":"10.1002\/anie.202208204","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T18:05:32Z","timestamp":1660327532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Palladium\u2010Catalyzed Aryldifluoromethylation of Aryl Halides with Aryldifluoromethyl Trimethylsilanes"],"prefix":"10.1002","volume":"61","author":[{"given":"Kyoungmin","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Chemistry University of California  Berkeley CA 94720 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Mormino","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of California  Berkeley CA 94720 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Kalkman","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of California  Berkeley CA 94720 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of California  Berkeley CA 94720 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-468X","authenticated-orcid":false,"given":"John F.","family":"Hartwig","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of California  Berkeley CA 94720 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1142\/p746"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9783527651351"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00258"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00392"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01788"},{"key":"e_1_2_7_7_1","unstructured":"Commercial pharmaceuticals containing difluoromethylene linkage searched by Drugbank: Cedazuridine Gemcitabine Glecaprevir Ivosidenib Ledipasvir Lubiprostone Maraviroc Tafluprost Vinflunine and Voxilaprevir."},{"key":"e_1_2_7_8_1","unstructured":"\u00a0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm990496z"},{"key":"e_1_2_7_10_2","doi-asserted-by":"crossref","unstructured":"J. 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