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Current efforts to synthesize spiro[azetidine\u2010indolines] are limited to chiral spiro[azetidine\u20102,3\u2032\u2010indolines]. Asymmetric synthesis of structurally similar chiral spiro[azetidine\u20103,3\u2032\u2010indolines] remains unexplored. In this work, the first copper(I)\u2010catalyzed asymmetric Kinugasa\/aryl C\u2212C coupling cascade reaction is described. This provides a straightforward access to densely functionalized chiral spiro[azetidine\u20103,3\u2032\u2010indoline]\u20102,2\u2032\u2010diones in good yields and with high enantioselectivity.<\/jats:p>","DOI":"10.1002\/anie.202208323","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T15:31:27Z","timestamp":1662132687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Asymmetric Synthesis of Spiro[Azetidine\u20103,3\u2032\u2010Indoline]\u20102,2\u2032\u2010Diones via Copper(I)\u2010Catalyzed Kinugasa\/C\u2212C Coupling Cascade Reaction"],"prefix":"10.1002","volume":"61","author":[{"given":"Xianqiang","family":"Zhong","sequence":"first","affiliation":[{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE) College of Pharmacy Jinan University  No. 601 Huangpu Avenue West Guangzhou 510632 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meirong","family":"Huang","sequence":"additional","affiliation":[{"name":"Shenzhen Bay Laboratory State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School  Shenzhen 518055 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huilan","family":"Xiong","sequence":"additional","affiliation":[{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE) College of Pharmacy Jinan University  No. 601 Huangpu Avenue West Guangzhou 510632 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhen","family":"Liang","sequence":"additional","affiliation":[{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE) College of Pharmacy Jinan University  No. 601 Huangpu Avenue West Guangzhou 510632 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE) College of Pharmacy Jinan University  No. 601 Huangpu Avenue West Guangzhou 510632 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-3275","authenticated-orcid":false,"given":"Qian","family":"Cai","sequence":"additional","affiliation":[{"name":"International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE) College of Pharmacy Jinan University  No. 601 Huangpu Avenue West Guangzhou 510632 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"For selected reviews of \u03b2-lactams and oxindole see:"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.09.008"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389557043487501"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr300135y"},{"key":"e_1_2_3_5_1","unstructured":"\u00a0"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo060084f"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-010-9354-x"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00418"},{"key":"e_1_2_3_9_2","unstructured":"H.He W.Shi Z.Jiang L.Han J.Sun J.Li S.Chen WO 2015085844 2015;"},{"key":"e_1_2_3_10_2","unstructured":"G.Chen T. 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These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum KarlsruheAccess Structures service."},{"key":"e_1_2_3_76_1","unstructured":"No desired products were observed for other nitrones withN-benzyl orN-t-butyl substituents."},{"key":"e_1_2_3_77_1","unstructured":"The dr value of3\u2009aswas determined by1H NMR analysis."},{"key":"e_1_2_3_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/JR9290001870"},{"key":"e_1_2_3_79_1","first-page":"281","volume-title":"Modern copper-catalyzed Hurtley reaction: efficient C-arylation of C-H acid, in Copper-mediated cross-coupling reactions","author":"Beletskaya I. 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