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However, the development of convergent synthetic methods to access them remains challenging. Herein, we report the Lewis acid catalyzed (4+3) annulative addition of aryl and amino donor\u2010acceptor cyclopropanes with 2\u2010aza\u20101,3\u2010dienes. Densely substituted azepane derivatives were obtained in good to excellent yields and with high diastereoselectivity. The reaction occurred under mild conditions with ytterbium triflate as the catalyst. The use of copper triflate with a trisoxazoline (Tox) ligand led to an enantioselective transformation. The obtained cycloadducts were convenient substrates for a series of further modifications, showing the synthetic utility of these compounds.<\/jats:p>","DOI":"10.1002\/anie.202209006","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T09:10:26Z","timestamp":1657789826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["(4+3) Annulation of Donor\u2010Acceptor Cyclopropanes and Azadienes: Highly Stereoselective Synthesis of Azepanones"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-8206","authenticated-orcid":false,"given":"Stefano","family":"Nicolai","sequence":"first","affiliation":[{"name":"Laboratory of Catalysis and Organic Synthesis Institute of Chemical Sciences and Engineering Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-914X","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Waser","sequence":"additional","affiliation":[{"name":"Laboratory of Catalysis and Organic Synthesis Institute of Chemical Sciences and Engineering Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"e_1_2_3_1_1","volume-title":"Handbook of Naturally Occurring Compounds, Vol.\u20052","author":"Devon T. 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