{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:39:08Z","timestamp":1770975548613,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of alkylthio electrophiles in synthesis has remained elusive because of the lack of a suitable reagent that is practical and of excellent enantioselectivity and appropriate reactivity. In this work we introduce a novel alkylthio reagent based on the 2\u2010mercapto\u20105\u2010methyl\u20101,3,4\u2010thiadiazole (MMTD) fragment for direct alkylsulfenylation of ketones and aldehydes. It can be readily prepared by the oxidative coupling between thiadiazole and other alkylthio reagents and be combined with chiral primary aminocatalysis. This protocol provides facile access to diverse \u03b1\u2010alkylthio quaternary carbon centers with good stereoselectivities.<\/jats:p>","DOI":"10.1002\/anie.202209044","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T02:23:45Z","timestamp":1659147825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Catalytic Asymmetric \u03b1\u2010Alkylsulfenylation with a Disulfide Reagent"],"prefix":"10.1002","volume":"61","author":[{"given":"Mingying","family":"Shi","sequence":"first","affiliation":[{"name":"College of Chemistry Beijing Normal University  Beijing 100875 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Basic Molecular Science (CBMS) Department of Chemistry Tsinghua University  Beijing 100084 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