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Herein, we report a reversible ratiometric photoacoustic (PA) imaging nanoprobe (<jats:bold>1<\/jats:bold>\u2010PAIN) for the real\u2010time imaging of \u22c5OH\/H<jats:sub>2<\/jats:sub>S redox cycle in vivo.<jats:bold>1<\/jats:bold>\u2010PAIN displays a low PA ratio between 690 and 825\u2005nm (PA<jats:sub>690<\/jats:sub>\/PA<jats:sub>825<\/jats:sub>), which significantly increases by \u22485\u2010fold upon oxidation by \u22c5OH, and is switched back to the initially low PA<jats:sub>690<\/jats:sub>\/PA<jats:sub>825<\/jats:sub>value upon reduction by H<jats:sub>2<\/jats:sub>S.<jats:bold>1<\/jats:bold>\u2010PAIN could dynamically report on the hepatic \u22c5OH production in mice during the lipopolysaccharide (LPS)\u2010induced liver inflammation process, and visualize hepatic H<jats:sub>2<\/jats:sub>S generation during the<jats:italic>N<\/jats:italic>\u2010acetyl cysteine (NAC)\u2010induced anti\u2010inflammation process.<jats:bold>1<\/jats:bold>\u2010PAIN can act as a useful tool to probe the redox state in living biology, beneficial for the study of redox imbalance\u2010related diseases.<\/jats:p>","DOI":"10.1002\/anie.202209248","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T08:05:07Z","timestamp":1658217907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["A Ratiometric Photoacoustic Probe with a Reversible Response to Hydrogen Sulfide and Hydroxyl Radicals for Dynamic Imaging of Liver Inflammation"],"prefix":"10.1002","volume":"61","author":[{"given":"Luyan","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science Chemistry and Biomedicine Innovation Center (ChemBIC) School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 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