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Here, we design a room\u2010temperature reaction to trap reaction intermediates in the prenucleation stage of ZnSe QDs (as a model system). We show that the trapped intermediate can transform to magic\u2010size clusters (MSCs) via intra\u2010molecular reorganization and can fragment to enable the growth of QDs. The MSCs exhibit a sharp optical absorption peaking at 299\u2005nm, labelled MSC\u2010299. The intermediate, the precursor compound (PC\u2010299) of MSC\u2010299, is optically transparent at 299\u2005nm and to longer wavelengths. This intermediate forms in various Zn and Se reaction systems. The present study provides unambiguous evidence that the nonclassical and classical pathways are both necessary to explain the nucleation and growth of aqueous\u2010phase QDs, with the former pathway favored more by high reaction concentrations.<\/jats:p>","DOI":"10.1002\/anie.202209615","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T01:08:17Z","timestamp":1659316097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Manipulating Reaction Intermediates to Aqueous\u2010Phase ZnSe Magic\u2010Size Clusters and Quantum Dots at Room Temperature"],"prefix":"10.1002","volume":"61","author":[{"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"National Engineering Research Center in Biomaterials College of Biomedical Engineering Sichuan University Chengdu Sichuan 610065 P. R. 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