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However, the synthetic application of N<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>is still underdeveloped mostly due to its inherent instability and the lack of reliable protocols for its preparation. This paper presents an open\u2010source setup and procedure for the on\u2010demand generation of anhydrous N<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>solution (up to 1\u2005M), which can be further used for reactions under batch and flow conditions. The accuracy and stability of N<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>concentration are guaranteed with the absence of head\u2010space in the setup and with the synchronization of the gas flows. The reliability of this protocol is demonstrated by &gt;30 worked examples in the nitrosative synthesis of heterocycles\u2014a library of structurally diverse benzotriazoles and sydnones. Kinetic and mechanistic aspects of the<jats:italic>N<\/jats:italic>\u2010nitrosative steps are also explored.<\/jats:p>","DOI":"10.1002\/anie.202210146","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T09:51:05Z","timestamp":1660643465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["On Demand Flow Platform for the Generation of Anhydrous Dinitrogen Trioxide and Its Further Use in<i>N<\/i>\u2010Nitrosative Reactions"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8612-8819","authenticated-orcid":false,"given":"Yuesu","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Integrated Technology and Organic Synthesis (CiTOS) MolSys Research Unit, University of Li\u00e8ge B6a, Room 3\/19, All\u00e9e du Six Ao\u00fbt 13 4000 Li\u00e8ge Sart Tilman Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4721-8635","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Renson","sequence":"additional","affiliation":[{"name":"Center for Integrated Technology and Organic Synthesis (CiTOS) MolSys Research Unit, University of Li\u00e8ge B6a, Room 3\/19, All\u00e9e du Six Ao\u00fbt 13 4000 Li\u00e8ge Sart Tilman Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-8846","authenticated-orcid":false,"given":"Jean\u2010Christophe M.","family":"Monbaliu","sequence":"additional","affiliation":[{"name":"Center for Integrated Technology and Organic Synthesis (CiTOS) MolSys Research Unit, University of Li\u00e8ge B6a, Room 3\/19, All\u00e9e du Six Ao\u00fbt 13 4000 Li\u00e8ge Sart Tilman Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1595\/003214058X24129134","volume":"2","author":"Hunt L.","year":"1958","journal-title":"Platinum Met. 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