{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:15:17Z","timestamp":1787166917330,"version":"build-2736575974"},"reference-count":84,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21621002, 21831009 and 21991110"],"award-info":[{"award-number":["21621002, 21831009 and 21991110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,10,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Direct\n                    <jats:italic>N<\/jats:italic>\n                    \u2010arylation of sulfonamides is a very attractive approach for preparing pharmaceutically important\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(hetero)aryl sulfonamides because it avoids the potential genotoxic problem resulting from the previous condensation method. Most known catalytic methods suffer from limited reaction scope and inconveniency on metal catalyst and ligand availability. Here we described that the combination of copper and oxalamides (or 4\u2010hydroxypicolinamides) offers a powerful catalytic system for\n                    <jats:italic>N<\/jats:italic>\n                    \u2010arylation of sulfonamides. A wide range of primary and secondary sulfonamides were able to couple with a series of (hetero)aryl bromides in the presence of 2\u20135\u2005mol\u2009% copper salts and oxalamides at 100\u2009\u00b0C. Coupling of primary sulfonamides with (hetero)aryl chlorides worked well under the catalysis of Cu\n                    <jats:sub>2<\/jats:sub>\n                    O and a 4\u2010hydroxypicolinamide. The catalytic method enabled direct sulfonamidation of four chloro\u2010containing marketed drugs and preparation of two sulfonamide drugs from the corresponding aryl halides.\n                  <\/jats:p>","DOI":"10.1002\/anie.202210483","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T14:58:58Z","timestamp":1662476338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Cu\u2010Catalyzed Coupling Reactions of Sulfonamides with (Hetero)Aryl Chlorides\/Bromides"],"prefix":"10.1002","volume":"61","author":[{"given":"Qiaoli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Science and Technology of China 96 Jinzhai Lu Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanting","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioorganic &amp; Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-7551","authenticated-orcid":false,"given":"Dawei","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioorganic &amp; Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"For recent reviews see:"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-018-0184-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871520617666171103140749"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01610"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.11.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm030480f"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml4000063"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9000488"},{"key":"e_1_2_7_9_1","first-page":"721","volume":"2","author":"Plumb J. 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