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From this class of donors, however, extremely low H\n                    <jats:sub>2<\/jats:sub>\n                    S releasing efficiencies have been reported and proper mechanistic studies have been omitted. Consequently, millimolar concentrations of arylthioamides are required to liberate just trace amounts of H\n                    <jats:sub>2<\/jats:sub>\n                    S, and via an unidentified mechanistic pathway, which obfuscates the interpretation of any biological activity that stems from their use. Herein, we report that H\n                    <jats:sub>2<\/jats:sub>\n                    S release from this valuable class of donors can be markedly enhanced through intramolecular nucleophilic assistance. Specifically, we demonstrate that both disulfide\u2010 and diselenide\u2010linked thioamides are responsive to biologically relevant concentrations of glutathione and release two molar equivalents of H\n                    <jats:sub>2<\/jats:sub>\n                    S via an intramolecular cyclization that significantly augments their rate and efficiency of sulfide delivery in both buffer and live human cells.\n                  <\/jats:p>","DOI":"10.1002\/anie.202210754","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T22:05:11Z","timestamp":1663193111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intramolecular Thiol\u2010 and Selenol\u2010Assisted Delivery of Hydrogen Sulfide"],"prefix":"10.1002","volume":"61","author":[{"given":"Qiwei","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Chemistry Wake Forest University  Wake Downtown Campus Winston-Salem NC 27101 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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