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However, the reported examples suffer from an inherent challenge as the reactivity is highly dependent on the torsional strain of the biaryl substrates, which significantly narrows down the scope and hampers the application. Herein, we report our discovery and development of a torsional strain\u2010independent reaction between biaryl thionolactones and activated isocyanides. By employing auto\u2010tandem silver catalysis, a universal synthesis of both<jats:italic>tri<\/jats:italic>\u2010 and<jats:italic>tetra<\/jats:italic>\u2010<jats:italic>ortho<\/jats:italic>\u2010substituted thiazole\u2010containing biaryls was realized in high yields with high enantioselectivities. In addition, these products could be facilely converted to a novel type of bridged biaryls bearing an eight\u2010membered lactone. Mechanistic studies were carried out to elucidate the cause of this unusual torsional strain\u2010independent reactivity.<\/jats:p>","DOI":"10.1002\/anie.202211303","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T10:35:06Z","timestamp":1661510106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Torsional Strain\u2010Independent Catalytic Enantioselective Synthesis of Biaryl Atropisomers"],"prefix":"10.1002","volume":"61","author":[{"given":"Zhang\u2010Hong","family":"Luo","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences and Hangzhou Institute of Innovative Medicine Zhejiang University Hangzhou 310058 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences and Hangzhou Institute of Innovative Medicine Zhejiang 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