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Current probes and drugs attempting to prevent \u03b2\u2010amyloid (A\u03b2) fibrosis encounter failures due to the blood\u2013brain barrier (BBB) penetration challenge and blind intervention time window. Herein, we design a near\u2010infrared (NIR) aggregation\u2010induced emission (AIE) probe, DNTPH, via balanced hydrophobicity\u2010hydrophilicity strategy. DNTPH binds selectively to A\u03b2 fibrils with a high signal\u2010to\u2010noise ratio. In vivo imaging revealed its excellent BBB permeability and long\u2010term tracking ability with high\u2010performance AD diagnosis. Remarkably, DNTPH exhibits a strong inhibitory effect on A\u03b2 fibrosis and promotes fibril disassembly, thereby attenuating A\u03b2\u2010induced neurotoxicity. DNTPH treatment significantly reduced A\u03b2 plaques and rescued learning deficits in AD mice. 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