{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T15:20:48Z","timestamp":1768749648057,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018693","name":"HORIZON EUROPE Framework Programme","doi-asserted-by":"publisher","award":["\"ImplantSens\" [813006]"],"award-info":[{"award-number":["\"ImplantSens\" [813006]"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2022,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the success of continuous glucose measuring systems operating through the skin for about 14\u2005days, long\u2010term implantable biosensors are facing challenges caused by the foreign\u2010body reaction. We present a conceptually new strategy using catalytic enzyme\u2010based biosensors based on a measuring sequence leading to minimum disturbance of the substrate equilibrium concentration by controlling the sensor between \u201con\u201d and \u201coff\u201d state combined with short potentiometric data acquisition. It is required that the enzyme activity can be completely switched off and no parasitic side reactions allow substrate turnover. This is achieved by using an O<jats:sub>2<\/jats:sub>\u2010independent FAD\u2010dependent glucose dehydrogenase embedded within a crosslinked redox polymer. A short measuring interval allows the glucose concentration equilibrium to be restored quickly which enables the biosensor to operate under quasi\u2010equilibrium conditions.<\/jats:p>","DOI":"10.1002\/anie.202211559","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T02:12:05Z","timestamp":1666059125000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Catalytic Biosensors Operating under Quasi\u2010Equilibrium Conditions for Mitigating the Changes in Substrate Diffusion"],"prefix":"10.1002","volume":"61","author":[{"given":"Anna","family":"Muhs","sequence":"first","affiliation":[{"name":"Analytical Chemistry\u2014Center for Electrochemical Sciences Faculty of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstrasse 150 44780 Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Bobrowski","sequence":"additional","affiliation":[{"name":"Analytical Chemistry\u2014Center for Electrochemical Sciences Faculty of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstrasse 150 44780 Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lielp\u0113tere","sequence":"additional","affiliation":[{"name":"Analytical Chemistry\u2014Center for Electrochemical Sciences Faculty of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstrasse 150 44780 Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-5223","authenticated-orcid":false,"given":"Wolfgang","family":"Schuhmann","sequence":"additional","affiliation":[{"name":"Analytical Chemistry\u2014Center for Electrochemical Sciences Faculty of Chemistry and Biochemistry Ruhr University Bochum  Universit\u00e4tsstrasse 150 44780 Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2018.05.004"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr068123a"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar9002015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/electronics6030065"},{"key":"e_1_2_7_5_1","unstructured":"\u00a0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2014.0378"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0956-5663(01)00306-2"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.3.E561"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2017.0050"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1932296814559746"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0222"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0077"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296815601869"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201200167"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/elan.201400097"},{"key":"e_1_2_7_16_1","unstructured":"\u00a0"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1525"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13726"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2019.0020"},{"key":"e_1_2_7_20_1","unstructured":"\u00a0"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/b802293c"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201400251"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0028"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja047728q"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2012.11.016"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-016-9982-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2021.113888"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2022.140798"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.09.099"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar00173a002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2859-10-106"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.051904-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00104a006"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB02461A"},{"key":"e_1_2_7_35_1","unstructured":"\u00a0"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coelec.2017.06.007"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2020.107487"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.electacta.2012.02.053"},{"key":"e_1_2_7_39_1","unstructured":"\u00a0"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1149\/2.0021812jes"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b05467"},{"key":"e_1_2_7_42_1","unstructured":"\u00a0"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1039\/cs9942300289"},{"key":"e_1_2_7_44_2","volume-title":"Electrochemical Methods. Fundamentals and Applications","author":"Bard A. J.","year":"2001"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31535-5"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/elan.201600575"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202211559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202211559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202211559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T16:15:49Z","timestamp":1712074549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202211559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,23]]},"references-count":46,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2022,12,23]]}},"alternative-id":["10.1002\/anie.202211559"],"URL":"https:\/\/doi.org\/10.1002\/anie.202211559","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,23]]},"assertion":[{"value":"2022-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202211559"}}