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However, general access to <jats:italic>N<\/jats:italic>\u2212CF<jats:sub>3<\/jats:sub> compounds simply from <jats:italic>N<\/jats:italic>\u2212CF<jats:sub>3<\/jats:sub> secondary amines is hampered by the challenging preparation and instability of these amines, as well as a much lower reactivity due to the strong electron\u2010withdrawing nature and steric bulk of the trifluoromethyl moiety. Herein, we report a general and highly efficient synthesis of <jats:italic>N<\/jats:italic>\u2212CF<jats:sub>3<\/jats:sub> secondary amines with excellent isolated yields via the addition of the in situ generated difluoromethyl imine (R\u2212N=CF<jats:sub>2<\/jats:sub>) intermediates with hydrogen fluoride, which is mildly produced by triethylsilane and silver fluoride. <jats:italic>N<\/jats:italic>\u2212CF<jats:sub>3<\/jats:sub> sulfonamides, highly desirable but scarce at present, are easily accessible from these valuable building blocks through an unprecedented route. This study will bring new vitality to the synthesis of <jats:italic>N<\/jats:italic>\u2212CF<jats:sub>3<\/jats:sub> compounds.<\/jats:p>","DOI":"10.1002\/anie.202212115","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T02:20:28Z","timestamp":1665627628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["General Access to <i>N<\/i>\u2212CF<sub>3<\/sub> Secondary Amines and Their Transformation to <i>N<\/i>\u2212CF<sub>3<\/sub> Sulfonamides"],"prefix":"10.1002","volume":"61","author":[{"given":"Leibing","family":"Wang","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanjing University of Science and Technology  Nanjing 210094 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