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Herein, we firstly develop an approach that enables spatiotemporally controlled formation and rotation of magnetic nanochains in vivo, allowing for precise mechanotherapy of tumor. The nanochain comprised nanocomposites of pheophorbide\u2010A (PP) modified iron oxide nanoparticle (IONP) and lanthanide\u2010doped down\u2010conversion NP (DCNP). In a permanent magnetic field, the nanocomposites would be aligned to form nanochain. Next, MnO<jats:sub>2<\/jats:sub> NPs were subsequently administered to accumulate in tumor as suppliers of Mn<jats:sup>2+<\/jats:sup>, which coordinates with PP to immobilize the nanochain. In a rotating magnetic field, the nanochain would rapidly rotate, leading to apoptosis\/necrosis of tumor cell. The nanochain showed high <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>\u2010MR and NIR\u2010II fluorescence imaging signals, which facilitated guided therapy. The strategy has great potential in practical applications.<\/jats:p>","DOI":"10.1002\/anie.202213319","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T01:59:55Z","timestamp":1666922395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors"],"prefix":"10.1002","volume":"61","author":[{"given":"Qinrui","family":"Fu","sequence":"first","affiliation":[{"name":"Fujian Science &amp; Technology Innovation Laboratory for Optoelectronic Information of China MOE key laboratory for analytical science of food safety and biology College of Chemistry Fuzhou University  Fuzhou 350108 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Fujian Science &amp; Technology Innovation Laboratory for Optoelectronic Information of China MOE key laboratory for analytical science of food safety and biology College of Chemistry Fuzhou University  Fuzhou 350108 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luntao","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Science &amp; Technology Innovation Laboratory for Optoelectronic Information of China MOE key laboratory for analytical science of food safety and biology College of Chemistry Fuzhou University  Fuzhou 350108 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics &amp; Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University  Xiamen Fujian, 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjie","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy Engineering Southern University of Science and Technology  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics &amp; Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University  Xiamen Fujian, 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengzhi","family":"Hu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy Engineering Southern University of Science and Technology  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics &amp; Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University  Xiamen Fujian, 361005 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanghao","family":"Yang","sequence":"additional","affiliation":[{"name":"Fujian Science &amp; Technology Innovation Laboratory for Optoelectronic Information of China MOE key laboratory for analytical science of food safety and biology College of Chemistry Fuzhou University  Fuzhou 350108 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4771-5006","authenticated-orcid":false,"given":"Jibin","family":"Song","sequence":"additional","affiliation":[{"name":"Fujian Science &amp; Technology Innovation Laboratory for Optoelectronic Information of China MOE key laboratory for analytical science of food safety and biology College of Chemistry Fuzhou University  Fuzhou 350108 China"},{"name":"College of Chemistry Beijing University of Chemical Technology  Beijing 10010 P. 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