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A platinum(IV) complex OPA derived from oxaliplatin (OP) and artesunate (ART) exhibited direct cytotoxicity against human colon cancer cells and immunomodulatory activity to inhibit TREM2 on macrophages in vitro and vivo. Furthermore, OPA deterred the tumor growth in mouse models bearing MC38 colorectal tumor by reducing the number of CD206\n                    <jats:sup>+<\/jats:sup>\n                    and CX\n                    <jats:sub>3<\/jats:sub>\n                    CR1\n                    <jats:sup>+<\/jats:sup>\n                    immunosuppressive macrophages; it also promoted the expansion and infiltration of immunostimulatory dendritic, cytotoxic T, and natural killer cells. 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