{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:35:46Z","timestamp":1791974146907,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["2R01GM109054"],"award-info":[{"award-number":["2R01GM109054"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herein we report the development of deacylative thiolation of diverse methyl ketones. The reaction is redox\u2010neutral, and heavy\u2010metal\u2010free, which provides a new way to introduce thioether groups site\u2010specifically to unactivated aliphatic positions. It also features excellent functional group tolerance and broad substrate scope, thus allowing late\u2010stage derivatization. The process benefits from efficient condensation between the activation reagent and ketone substrates, which triggers aromatization\u2010driven C\u2212C fragmentation and rapid radical coupling with thiosulfonates. Experimental and computational mechanistic studies suggest the involvement of a radical chain pathway.<\/jats:p>","DOI":"10.1002\/anie.202213691","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T18:04:21Z","timestamp":1676657061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Deacylative Thiolation by Redox\u2010Neutral Aromatization\u2010Driven C\u2212C Fragmentation of Ketones"],"prefix":"10.1002","volume":"62","author":[{"given":"Xukai","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Chemistry The University of Chicago  5735 S Ellis Ave Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Chicago  5735 S Ellis Ave Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zining","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Chicago  5735 S Ellis Ave Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-6015","authenticated-orcid":false,"given":"Guangbin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Chemistry The University of Chicago  5735 S Ellis Ave Chicago IL 60637 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"e_1_2_3_1_1","first-page":"1335","volume-title":"March's advanced organic chemistry: reactions, mechanisms, and structure","author":"March 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