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The challenging 1,2\u2010<jats:italic>cis<\/jats:italic>\u2010furanoside, a core structure of the A201 family, was obtained by remote 2\u2010quinolinecarbonyl\u2010assisted glycosylation. We accomplished the total synthesis of A201A and A201E based on the critical 1,2\u2010<jats:italic>cis<\/jats:italic>\u2010furanoside moiety through late\u2010stage glycosylation without any interference from basic dimethyl adenosine. We also confirmed the absolute configuration of A201E by total synthesis. This modular synthesis strategy enables efficient preparation of A201 family antibiotics, allowing the study of their structure\u2013activity relationships and mode of action. This study satisfies the increasing demand for developing novel antibiotics inspired by the A201 family.<\/jats:p>","DOI":"10.1002\/anie.202213810","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T03:21:29Z","timestamp":1669087289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bioinspired Total Synthesis of Complex Nucleoside Antibiotics A201A, A201D and A201E"],"prefix":"10.1002","volume":"62","author":[{"given":"Jiaxiang","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Applied Organic Chemistry Department of Chemistry and School of Pharmacy Lanzhou University  Lanzhou 730000 P. R. 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Prof. Jianhua Ju provided the original NMR spectra files of A201E."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202213810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202213810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202213810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T15:56:46Z","timestamp":1692460606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202213810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,1,16]]}},"alternative-id":["10.1002\/anie.202213810"],"URL":"https:\/\/doi.org\/10.1002\/anie.202213810","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"type":"print","value":"1433-7851"},{"type":"electronic","value":"1521-3773"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"2022-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202213810"}}