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However, practical applications have thus far been plagued by the low activity and the requirement of complex equipment. Here, inspired by the process of biological hydrogen peroxide synthesis catalyzed by enzymes, we report a Pt\u2010Au alloy to mimic the catalytic function of natural formate oxidase for hydrogen peroxide synthesis through aerobic oxidation of formic acid. The mass activity of the Pt\u2010Au alloy is three times higher than that of formate oxidase. Density functional theory calculations revealed that the efficient dehydrogenation of formic acid and the high selectivity of the subsequent reduction of oxygen to hydrogen peroxide account for the high hydrogen peroxide productivity. In addition, the formic acid aqueous solution provides an acidic environment, which is conducive to the utilization of the in situ generated hydrogen peroxide for oxidation reactions, including C\u2212H bond oxidation and sterilization.<\/jats:p>","DOI":"10.1002\/anie.202213930","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T15:04:48Z","timestamp":1664895888000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Platinum\u2010Gold Alloy Catalyzes the Aerobic Oxidation of Formic Acid for Hydrogen Peroxide Synthesis"],"prefix":"10.1002","volume":"61","author":[{"given":"Jinxing","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun 130022 China"},{"name":"University of Science and Technology of China  Hefei 230026 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