{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:56:39Z","timestamp":1792220199836,"version":"4.4.0"},"reference-count":113,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001703","name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report herein the first examples of chiral phosphoric acid\u2010catalyzed enantioselective Diels\u2013Alder reactions between 2\u2010trifluoroacetamido\u20101,3\u2010dienes <jats:bold>1<\/jats:bold> and \u03b1,\u03b2\u2010unsaturated carbonyl compounds <jats:bold>2<\/jats:bold>. Polysubstituted 1\u2010acetamido cyclohexenes <jats:bold>3<\/jats:bold> were formed in high yields with excellent diastereo\u2010 and enantioselectivities. The reaction proceeds through a stepwise process as shown by deuterium labelling experiments. A catalytic enantioselective three\u2010component reaction of <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold> and <jats:italic>ortho<\/jats:italic>\u2010hydroxybenzhydryl alcohols <jats:bold>4<\/jats:bold> was subsequently developed furnishing the densely functionalized hexahydroxanthenes <jats:bold>5<\/jats:bold> in a highly stereoselective manner. This multicomponent reaction generates four chemical bonds with concurrent creation of five contiguous stereocenters.<\/jats:p>","DOI":"10.1002\/anie.202214925","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T03:02:31Z","timestamp":1667962951000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Organocatalytic Enantioselective Diels\u2013Alder Reaction of 2\u2010Trifluoroacetamido\u20101,3\u2010dienes with \u03b1,\u03b2\u2010Unsaturated Ketones"],"prefix":"10.1002","volume":"62","author":[{"given":"Xin\u2010Qi","family":"Zhu","sequence":"first","affiliation":[{"name":"Laboratory of Synthesis and Natural Products (LSPN) Institute of Chemical Sciences and Engineering Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne EPFL-SB-ISIC-LSPN BCH 5304  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis and Natural Products (LSPN) Institute of Chemical Sciences and Engineering Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne EPFL-SB-ISIC-LSPN BCH 5304  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-6689","authenticated-orcid":false,"given":"Jieping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Synthesis and Natural Products (LSPN) Institute of Chemical Sciences and Engineering Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne EPFL-SB-ISIC-LSPN BCH 5304  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19284600106"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020517)41:10<1650::AID-ANIE1650>3.0.CO;2-B"},{"key":"e_1_2_3_3_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020517)114:10<1724::AID-ANGE1724>3.0.CO;2-Q"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020517)41:10<1668::AID-ANIE1668>3.0.CO;2-Z"},{"key":"e_1_2_3_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20020517)114:10<1742::AID-ANGE1742>3.0.CO;2-Y"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201201636"},{"key":"e_1_2_3_5_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201201636"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar3000822"},{"key":"e_1_2_3_7_1","unstructured":"\u00a0"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00832a031"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar00072a006"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)86747-2"},{"key":"e_1_2_3_11_1","unstructured":"\u00a0"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo970438q"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja971272d"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja9921930"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja002058j"},{"key":"e_1_2_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/424146a"},{"key":"e_1_2_3_17_1","unstructured":"\u00a0"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01267a098"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00405a017"},{"key":"e_1_2_3_20_1","unstructured":"\u00a0"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4020(77)80463-8"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1039\/a704289b"},{"key":"e_1_2_3_23_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/jlac.199619960702","author":"Enders 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