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In recent years, the utilization of Tf<jats:sub>2<\/jats:sub>O as an activator for nitrogen\u2010containing heterocycles, nitriles and nitro groups has become a promising tool for the development of new valuable methods with considerable success. In addition, Tf<jats:sub>2<\/jats:sub>O has been used as an efficient radical trifluoromethylation and trifluoromethylthiolation reagent due to the contained SO<jats:sub>2<\/jats:sub>CF<jats:sub>3<\/jats:sub>fragment, and significant progress has been made in this area. This review summarizes the recent progress in the applications of Tf<jats:sub>2<\/jats:sub>O in the above two aspects, and aims to illustrate the role and potential application of this reagent in organic synthesis.<\/jats:p>","DOI":"10.1002\/anie.202215008","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T12:47:45Z","timestamp":1671626865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Recent Applications of Trifluoromethanesulfonic Anhydride in Organic Synthesis"],"prefix":"10.1002","volume":"62","author":[{"given":"Qixue","family":"Qin","sequence":"first","affiliation":[{"name":"College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University Qingdao Shandong 266109 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengrui","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Rd. 38 Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-9034","authenticated-orcid":false,"given":"Ning","family":"Jiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Xue Yuan Rd. 38 Beijing 100191 China"},{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal University Shanghai 200062 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"e_1_2_10_1_1","unstructured":"\u00a0"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(00)00093-4"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.05.107"},{"key":"e_1_2_10_4_2","volume-title":"Encyclopedia of Reagents for Organic Synthesis","author":"Mart\u00ednez A. 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