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Herein, we report on a palladium\u2010catalyzed C\u2212H arylation of tryptophan\u2010containing peptides with readily accessible and modular arylthianthrenium salts. Under exceedingly mild reaction conditions, the late\u2010stage diversification of structurally complex peptides was accomplished. The tunability and ease of preparation of arylthianthrenium salts allowed the expedient stitching of tryptophan\u2010containing peptides with drug, natural product, and peptidic scaffolds by forging sterically congested biaryl linkages. The robustness of the palladium catalysis regime was reflected by the full tolerance of a plethora of sensitive and coordinating functional groups. Hence, our manifold enabled efficient access to highly decorated, labelled, conjugated, and ligated linear and cyclic peptides.<\/jats:p>","DOI":"10.1002\/anie.202216661","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T22:11:11Z","timestamp":1672351871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Late\u2010stage C\u2212H Functionalization of Tryptophan\u2010Containing Peptides with Thianthrenium Salts: Conjugation and Ligation"],"prefix":"10.1002","volume":"62","author":[{"given":"Nikolaos","family":"Kaplaneris","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen  Tammanstrasse 2 37077 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Puet","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Organische und 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