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In this work, we developed a novel cyclometalated Pt<jats:sup>IV<\/jats:sup>\u2010terthiophene complex,<jats:bold>Pt3<\/jats:bold>, that not only induces DNA damage and cellular metabolism dysregulation, but also disrupts zinc homeostasis as indicated by the abnormal transcriptional level of zinc regulatory proteins, excess accumulation of Zn<jats:sup>2+<\/jats:sup>in cytoplasm, and down\u2010regulation of metallothioneins (MTs), which further caused redox imbalance. The simultaneous disruption of zinc and redox homeostasis in response to<jats:bold>Pt3<\/jats:bold>treatment activated gasdermin\u2010D mediated pyroptosis accompanied by cytoskeleton remodeling, thus releasing pro\u2010inflammatory cytokines to promote dendritic cell (DC) maturation and T cell tumor\u2010infiltration, eventually eliminating both primary and distant tumors in vivo. 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