{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:28:37Z","timestamp":1786976917055,"version":"build-2736575974"},"reference-count":102,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["200020_181974"],"award-info":[{"award-number":["200020_181974"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A water\u2010soluble coordination cage was obtained by reaction of Pd(NO\n                    <jats:sub>3<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    with a 1,3\u2010di(pyridin\u20103\u2010yl)benzene ligand featuring a short PEG chain. The cavity of the metal\u2010organic cage contains one nitrate anion, which is readily replaced by chloride. The apparent association constant for chloride binding in buffered aqueous solution is\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    =1.8(\u00b10.1)\u00d710\n                    <jats:sup>5<\/jats:sup>\n                    \u2005M\n                    <jats:sup>\u22121<\/jats:sup>\n                    . This value is significantly higher than what has been reported for other macrocyclic chloride receptors. The heavier halides Br\n                    <jats:sup>\u2212<\/jats:sup>\n                    and I\n                    <jats:sup>\u2212<\/jats:sup>\n                    compete with binding or self\u2010assembly, but the receptor displays very good selectivity over common anions such as phosphate, acetate, carbonate, and sulfate. A further increase of the chloride binding affinity by a factor of 3 was achieved using a fluorinated dipyridyl ligand.\n                  <\/jats:p>","DOI":"10.1002\/anie.202218072","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T04:21:26Z","timestamp":1673410886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Synthetic Receptors with Micromolar Affinity for Chloride in Water"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3572-6122","authenticated-orcid":false,"given":"Sylvain","family":"Sudan","sequence":"first","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4710-8129","authenticated-orcid":false,"given":"Cesare","family":"Berton","sequence":"additional","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7515-7593","authenticated-orcid":false,"given":"Farzaneh","family":"Fadaei\u2010Tirani","sequence":"additional","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-7234","authenticated-orcid":false,"given":"Kay","family":"Severin","sequence":"additional","affiliation":[{"name":"Institut des Sciences et Ing\u00e9nierie Chimiques Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"e_1_2_3_1_1","unstructured":"\u00a0"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2021.10.029"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00458"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201506589"},{"key":"e_1_2_3_4_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201506589"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/b926166b"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-005-0601-6"},{"key":"e_1_2_3_7_1","unstructured":"For examples see:"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw5145"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2018.11.008"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b00219"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201411805"},{"key":"e_1_2_3_11_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201411805"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201002748"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200704717"},{"key":"e_1_2_3_13_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200704717"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503121"},{"key":"e_1_2_3_14_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200503121"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja016796z"},{"key":"e_1_2_3_16_1","unstructured":"For chloride binding in solvent mixtures containing water see:"},{"key":"e_1_2_3_17_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC05037K"},{"key":"e_1_2_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2019.02.023"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2017.08.003"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja4074744"},{"key":"e_1_2_3_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/b510068b"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja026996q"},{"key":"e_1_2_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010716)40:14<2648::AID-ANIE2648>3.0.CO;2-#"},{"key":"e_1_2_3_23_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20010716)113:14<2722::AID-ANGE2722>3.0.CO;2-Z"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201700111"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b02846"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201409895"},{"key":"e_1_2_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201409895"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC00990H"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4OB02211D"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01722"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.7b00867"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC03638D"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2111"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b00148"},{"key":"e_1_2_3_34_1","unstructured":"\u00a0"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01011a047"},{"key":"e_1_2_3_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00436a066"},{"key":"e_1_2_3_37_1","unstructured":"\u00a0"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.05.018"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(03)00019-5"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1039\/b926229f"},{"key":"e_1_2_3_41_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr9603845"},{"key":"e_1_2_3_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199500651"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19951070112"},{"key":"e_1_2_3_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC00127B"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202101057"},{"key":"e_1_2_3_45_1","unstructured":"Deposition numbers\u20052093122 ([Pd2(L1)4Cl](BF4)3) 2151102 ([Pd2(L1)4Br](BF4)3) 2151103 ([Pd2(L1)4I](BF4)3) 2224452 ([Pd2(L4)4(NO3)](NO3)3) and 2219635 ([Pd2(L4)4Cl](BF4)3)contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum KarlsruheAccess Structures service."},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60473J"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC01460H"},{"key":"e_1_2_3_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB01385J"},{"key":"e_1_2_3_49_1","unstructured":"For examples of reversible chloride coordination to water-soluble transition metal complexes see:"},{"key":"e_1_2_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201001287"},{"key":"e_1_2_3_51_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic1012878"},{"key":"e_1_2_3_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200304724"},{"key":"e_1_2_3_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0682(200209)2002:9<2312::AID-EJIC2312>3.0.CO;2-4"},{"key":"e_1_2_3_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20000818)39:16<2917::AID-ANIE2917>3.0.CO;2-0"},{"key":"e_1_2_3_54_3","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3757(20000818)112:16<3039::AID-ANGE3039>3.0.CO;2-Q"},{"key":"e_1_2_3_55_2","doi-asserted-by":"publisher","DOI":"10.1039\/a704318j"},{"key":"e_1_2_3_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic00179a026"},{"key":"e_1_2_3_57_1","unstructured":"For examples see:"},{"key":"e_1_2_3_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202115468"},{"key":"e_1_2_3_58_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202115468"},{"key":"e_1_2_3_59_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC02663A"},{"key":"e_1_2_3_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22984-6"},{"key":"e_1_2_3_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja5130379"},{"key":"e_1_2_3_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201408068"},{"key":"e_1_2_3_62_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201408068"},{"key":"e_1_2_3_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201203086"},{"key":"e_1_2_3_64_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3dt51709h"},{"key":"e_1_2_3_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107184"},{"key":"e_1_2_3_65_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201107184"},{"key":"e_1_2_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2004.10.016"},{"key":"e_1_2_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2022.109284"},{"key":"e_1_2_3_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201600259"},{"key":"e_1_2_3_69_1","unstructured":"For examples see:"},{"key":"e_1_2_3_70_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1DT01302E"},{"key":"e_1_2_3_71_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12800"},{"key":"e_1_2_3_72_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b03858"},{"key":"e_1_2_3_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1193"},{"key":"e_1_2_3_74_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja303355v"},{"key":"e_1_2_3_75_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19981217)37:23<3265::AID-ANIE3265>3.0.CO;2-B"},{"key":"e_1_2_3_75_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(19981204)110:23<3458::AID-ANGE3458>3.0.CO;2-I"},{"key":"e_1_2_3_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19980518)37:9<1258::AID-ANIE1258>3.0.CO;2-#"},{"key":"e_1_2_3_76_3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3757(19980504)110:9<1323::AID-ANGE1323>3.0.CO;2-C"},{"key":"e_1_2_3_77_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja971204r"},{"key":"e_1_2_3_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199618381"},{"key":"e_1_2_3_78_3","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19961081632"},{"key":"e_1_2_3_79_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60371G"},{"key":"e_1_2_3_80_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT04211K"},{"key":"e_1_2_3_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00672"},{"key":"e_1_2_3_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201506539"},{"key":"e_1_2_3_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201506539"},{"key":"e_1_2_3_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527644131.ch3"},{"key":"e_1_2_3_84_1","unstructured":"For reviews about nitrate receptors see:"},{"key":"e_1_2_3_85_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC01266J"},{"key":"e_1_2_3_86_2","doi-asserted-by":"publisher","DOI":"10.1080\/10610270701747610"},{"key":"e_1_2_3_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b08767"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202218072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202218072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202218072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T08:51:11Z","timestamp":1737017471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202218072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,24]]},"references-count":102,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,2,20]]}},"alternative-id":["10.1002\/anie.202218072"],"URL":"https:\/\/doi.org\/10.1002\/anie.202218072","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,24]]},"assertion":[{"value":"2022-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202218072"}}