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This system is applicable to a range of pro\u2010nucleophiles for access to sterically and electronically diverse \u03b1\u2010aryl or \u03b1,\u03b1\u2010diaryl ketones, which are ubiquitous substructures in biologically active compounds. The Josiphos SL\u2010J001\u20101\u2010based palladium catalyst was identified as the most efficient and selective, enabling carbonylative arylation with aryl bromides under 1\u2005atm CO to provide the ketone products without the formation of direct coupling byproducts. Additionally, (Josiphos)Pd(CO)\n                    <jats:sub>2<\/jats:sub>\n                    was identified as the catalyst resting state. A kinetic study suggests that the oxidative addition of aryl bromides is the turnover\u2010limiting step. Key catalytic intermediates were also isolated.\n                  <\/jats:p>","DOI":"10.1002\/anie.202300073","type":"journal-article","created":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T22:15:35Z","timestamp":1680473735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Palladium\u2010Catalyzed Benzylic C(sp\n                    <sup>3<\/sup>\n                    )\u2212H Carbonylative Arylation with Aryl Bromides"],"prefix":"10.1002","volume":"62","author":[{"given":"Bowen","family":"Hu","sequence":"first","affiliation":[{"name":"Roy and Diana Vagelos Laboratories Penn\/Merck Laboratory for High-Throughput Experimentation Department of Chemistry University of Pennsylvania  231 S.\u200534 Street Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Roy and Diana Vagelos Laboratories Penn\/Merck Laboratory for High-Throughput Experimentation Department of Chemistry University of Pennsylvania  231 S.\u200534 Street Philadelphia PA 19104 USA"},{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  11 Bei San Huan Dong Lu, Chaoyang District Beijing 100029 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Roy and Diana Vagelos Laboratories Penn\/Merck Laboratory for High-Throughput Experimentation Department of Chemistry University of Pennsylvania  231 S.\u200534 Street Philadelphia PA 19104 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8392-4150","authenticated-orcid":false,"given":"Patrick J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Roy and Diana Vagelos Laboratories Penn\/Merck Laboratory for High-Throughput Experimentation Department of Chemistry University of Pennsylvania  231 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