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Herein, we introduce concomitantly PEG backbone functionality and degradability via a one\u2010step modification with 1,2,4\u2010triazoline\u20103,5\u2010diones (TAD) under green light. The TAD\u2010PEG conjugates are degradable in aqueous medium under physiological conditions, with the rate of hydrolysis depending on pH and temperature. Subsequently, a PEG\u2010lipid is modified with TAD\u2010derivatives and successfully used for messenger RNA (mRNA) lipid nanoparticle (LNP) delivery, thereby improving mRNA transfection efficiency on multiple cell cultures in vitro. In vivo, in mice, mRNA LNP formulation exhibited a similar tissue distribution as common LNPs, with a slight decrease in transfection efficiency. 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