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Here we report an unprecedented highly enantioselective dynamic kinetic intermolecular P\u2212C coupling of SPOs and aryl iodides catalyzed by copper complexes ligated by a finely modified chiral 1,2\u2010diamine ligand. The reaction tolerates a wide range of SPOs and aryl iodides, affording <jats:italic>P<\/jats:italic>\u2010stereogenic tertiary phosphine oxides (TPOs) in high yields and with good enantioselectivity (average 89.2\u2009%\u2009ee). The resulting enantioenriched TPOs were transformed into structurally diverse <jats:italic>P<\/jats:italic>\u2010chiral scaffolds, which are highly valuable as ligands and catalysts in asymmetric synthesis.<\/jats:p>","DOI":"10.1002\/anie.202301628","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T16:29:00Z","timestamp":1681489740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Copper\u2010Catalyzed Dynamic Kinetic Asymmetric P\u2212C Coupling of Secondary Phosphine Oxides and Aryl Iodides"],"prefix":"10.1002","volume":"62","author":[{"given":"Jie","family":"Kang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Chemical Biology College of Pharmacy Nankai University  38 Tongyan Road, Jinnan District Tianjin 300350 P. R. 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