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However, such COFs are generally constructed using small\u2010molecule photosensitizers. Herein, we report that the reticular chemistry\u2010based synthesis of COFs from two inert monomers yields a COF\u2010based sonosensitizer (TPE\u2010NN) with inherent sonodynamic activity. Subsequently, a nanoscale COF TPE\u2010NN is fabricated and embedded with copper (Cu)\u2010coordinated sites to obtain TPE\u2010NN\u2010Cu. Results show that Cu coordination can enhance the sonodynamic effect of TPE\u2010NN, whereas ultrasound (US) irradiation for sonodynamic therapy can augment the chemodynamic efficacy of TPE\u2010NN\u2010Cu. Consequently, TPE\u2010NN\u2010Cu upon US irradiation shows high\u2010performance anticancer effects based on mutually reinforced sono\u2010\/chemo\u2010nanodynamic therapy. This study reveals the backbone\u2010originated sonodynamic activity of COFs and proposes a paradigm of intrinsic COF sonosensitizers for nanodynamic therapy.<\/jats:p>","DOI":"10.1002\/anie.202302146","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T03:25:59Z","timestamp":1678418759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Reticular Chemistry\u2010Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy"],"prefix":"10.1002","volume":"62","author":[{"given":"Yanqiu","family":"Duan","sequence":"first","affiliation":[{"name":"School of Medicine Shanghai University  Shanghai 200444 P. R. China"},{"name":"Materdicine Lab School of Life Sciences Shanghai University  Shanghai 200444 P. R. 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