{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:19:36Z","timestamp":1789658376268,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"25","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104036;"],"award-info":[{"award-number":["22104036;"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21735001"],"award-info":[{"award-number":["21735001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,6,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Precise quantification of trace components in whole blood via fluorescence is of great significance. However, the applicability of current fluorescent probes in whole blood is largely hindered by the strong blood autofluorescence. Here, we proposed a blood autofluorescence\u2010suppressed sensing strategy to develop an activable fluorescent probe for quantification of trace analyte in whole blood. Based on inner filter effect, by screening fluorophores whose absorption overlapped with the emission of blood, a redshift BODIPY quencher with an absorption wavelength ranging from 600\u2013700\u2005nm was selected for its superior quenching efficiency and high brightness. Two 7\u2010nitrobenzo[c] [1,2,5] oxadiazole ether groups were introduced onto the BODIPY skeleton for quenching its fluorescence and the response of H\n                    <jats:sub>2<\/jats:sub>\n                    S, a gas signal molecule that can hardly be quantified because of its low concentration in whole blood. Such detection system shows a pretty low background signal and high signal\u2010to\u2010back ratio, the probe thus achieved the accurate quantification of endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S in 20\u2010fold dilution of whole blood samples, which is the first attempt of quantifying endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S in whole blood. Moreover, this autofluorescence\u2010suppressed sensing strategy could be expanded to other trace analytes detection in whole blood, which may accelerate the application of fluorescent probes in clinical blood test.\n                  <\/jats:p>","DOI":"10.1002\/anie.202302957","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T06:34:10Z","timestamp":1682577250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A Quencher\u2010Based Blood\u2010Autofluorescence\u2010Suppression Strategy Enables the Quantification of Trace Analytes in Whole Blood"],"prefix":"10.1002","volume":"62","author":[{"given":"Zhiyang","family":"Yuwen","sequence":"first","affiliation":[{"name":"Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Institute of Interdisciplinary Studies College of Chemistry and Chemical Engineering Hunan Normal University  410082 Changsha P.\u2005R. 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