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Herein, the relay catalysis of a supported bifunctional cobalt catalyst with\n                    <jats:sc>l<\/jats:sc>\n                    \u2010proline has been successfully applied to establish a bran\u2010new reductive annulation reaction of nitroarenes and formaldehyde, which enables direct and diverse construction of both symmetrical and unsymmetrical 1,3\u2010diaryl imidazolines. It proceeds with operational simplicity, good substrate and functionality compatibility, and excellent step and atom\u2010efficiency. Mechanistic studies reveal that the Co\u2010catalyst exhibits a synergistic effect on the formation of key\n                    <jats:italic>N<\/jats:italic>\n                    \u2010hydroxy imine, and the\n                    <jats:sc>l<\/jats:sc>\n                    \u2010proline subsequently facilitates the key C\u2212C bond formation. The current work opens a door to develop useful transformations with nitroarenes by reduction\u2010interrupted strategy.\n                  <\/jats:p>","DOI":"10.1002\/anie.202303007","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T10:20:52Z","timestamp":1679480452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Utilizing Nitroarenes and HCHO to Directly Construct Functional N\u2010Heterocycles by Supported Cobalt\/Amino Acid Relay Catalysis"],"prefix":"10.1002","volume":"62","author":[{"given":"Jia\u2010Lu","family":"Sun","sequence":"first","affiliation":[{"name":"Key Lab of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology  Wushan Rd-381 Guangzhou 510641 P.R. 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