{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:14:19Z","timestamp":1792689259684,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"29","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["188573"],"award-info":[{"award-number":["188573"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,7,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reminiscent of Lochmann\u2010Schlosser superbase recipes, the addition of two molar equivalents of KO<jats:italic>t<\/jats:italic>Bu to Zn(TMP)<jats:sub>2<\/jats:sub> (TMP=2,2,6,6\u2010tetramethylpiperidide) transforms this mild zinc <jats:italic>bis<\/jats:italic>\u2010amide base to a powerful metalating agent able to perform facile regioselective zincation of a wide range of sensitive fluoroarenes. Structural authentication of the intermediates post Zn\u2212H exchange demonstrates activation of both TMP groups to form a range of higher order bis\u2010aryl potassium zincates, isolable as solids and further functionalized in electrophilic interception reactions. Studies assessing the role of KO<jats:italic>t<\/jats:italic>Bu reveal that the first equivalent undergoes co\u2010complexation with Zn(TMP)<jats:sub>2<\/jats:sub>, enabling kinetic activation of the amide groups; whereas the second equivalent stabilizes the metalated intermediate preventing ligand redistribution. Showcasing its metalating power, this bimetallic KO<jats:italic>t<\/jats:italic>Bu\/Zn(TMP)<jats:sub>2<\/jats:sub> partnership, can effect zincation of toluene and benzene at room temperature.<\/jats:p>","DOI":"10.1002\/anie.202303099","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T17:19:25Z","timestamp":1679591965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Alkali\u2010Metal\u2010Alkoxide Powered Zincation of Fluoroarenes Employing Zinc Bis\u2010Amide Zn(TMP)<sub>2<\/sub>"],"prefix":"10.1002","volume":"62","author":[{"given":"Neil R.","family":"Judge","sequence":"first","affiliation":[{"name":"Department f\u00fcr Chemie, Biochemie und Pharmazie Universit\u00e4t Bern  3012 Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3998-7506","authenticated-orcid":false,"given":"Eva","family":"Hevia","sequence":"additional","affiliation":[{"name":"Department f\u00fcr Chemie, Biochemie und Pharmazie Universit\u00e4t Bern  3012 Bern 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