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Deuterium labelling studies corroborate a novel reaction mechanism in which alkyne hydroruthenation forms a transient vinylruthenium complex that deprotonates the terminal alkyne to form the active alkynylruthenium nucleophile.<\/jats:p>","DOI":"10.1002\/anie.202303345","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T15:20:18Z","timestamp":1680276018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Ruthenium\u2010Catalyzed C\u2212C Coupling of Terminal Alkynes with Primary Alcohols or Aldehydes: \u03b1,\u03b2\u2010Acetylenic Ketones (Ynones) via Oxidative Alkynylation"],"prefix":"10.1002","volume":"62","author":[{"given":"Eliezer","family":"Ortiz","sequence":"first","affiliation":[{"name":"University of Texas at Austin Department of Chemistry  105 E 24th St. (A5300) Austin TX 78712-1167 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline 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