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As the \u03b1\u2010C\u2212H bond is far more acidic than the \u03b2\u2010C\u2212H bond, carbonyl compounds undergo highly regioselective allylation at the \u03b1\u2010position and their \u03b2\u2010allylation is therefore highly challenging. This innate \u03b1\u2010reactivity conversely hampers diversity, especially if the corresponding \u03b2\u2010allylation product is targeted. Herein, we present a formal intermolecular \u03b2\u2010C\u2212C bond formation reaction of a broad range of aldehydes and ketones with different allyl electrophiles through cooperative nickel and photoredox catalysis. \u03b2\u2010Selectivity is achieved via initial transformation of the aldehydes and ketones to their corresponding silyl enol ethers. The overall transformation features mild conditions, excellent regioselectivity, wide functional group tolerance and high reaction efficiency. The introduced facile and regioselective \u03b2\u2010allylation of carbonyl compounds proceeding through cooperative catalysis allows the preparation of valuable building blocks that are difficult to access from aldehydes and ketones using existing methodology.<\/jats:p>","DOI":"10.1002\/anie.202303473","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T16:15:06Z","timestamp":1683216906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Regioselective Formal \u03b2\u2010Allylation of Carbonyl Compounds Enabled by Cooperative Nickel and Photoredox Catalysis"],"prefix":"10.1002","volume":"62","author":[{"given":"Kun","family":"Liu","sequence":"first","affiliation":[{"name":"Organisch-Chemisches Institut Westf\u00e4lische Wilhelms-Universit\u00e4t  Corrensstra\u00dfe 40 48149 M\u00fcnster 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