{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:17:27Z","timestamp":1773346647910,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1127, project ID 239748522, subproject A01"],"award-info":[{"award-number":["SFB1127, project ID 239748522, subproject A01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Cluster of Excellence EXC2051 Balance of the Microverse (project-ID 390713860)"],"award-info":[{"award-number":["Cluster of Excellence EXC2051 Balance of the Microverse (project-ID 390713860)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 275\/442-1 FUGG"],"award-info":[{"award-number":["INST 275\/442-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016019","name":"Freistaat Th\u00fcringen","doi-asserted-by":"publisher","award":["2015 FGI 0021"],"award-info":[{"award-number":["2015 FGI 0021"]}],"id":[{"id":"10.13039\/100016019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Methanobactin OB3b (Mbn\u2010OB3b) is a unique natural product with stunning affinity for copper ions (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    \u2248Cu(I) 10\n                    <jats:sup>34<\/jats:sup>\n                    ). Here, we report the first total synthesis of Cu(I)\u2010bound methanobactin OB3b featuring as key transformations a cyclodehydration\u2010thioacylation sequence, to generate the conjugated heterocyclic systems, and a copper\u2010templated cyclization, to complete the caged structure of the very sensitive target compound.\n                  <\/jats:p>","DOI":"10.1002\/anie.202304901","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T01:50:21Z","timestamp":1688521821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Templated Total Synthesis of Cu(I)\u2010Methanobactin OB3b**"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3659-5434","authenticated-orcid":false,"given":"Emilia","family":"Cupioli","sequence":"first","affiliation":[{"name":"Friedrich-Schiller-Universit\u00e4t Institut f\u00fcr Organische Chemie und Makromolekulare Chemie  Humboldtstr. 10 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric J. M.","family":"Gaigne","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-Universit\u00e4t Institut f\u00fcr Organische Chemie und Makromolekulare Chemie  Humboldtstr. 10 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sachse","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-Universit\u00e4t Institut f\u00fcr Organische Chemie und Makromolekulare Chemie  Humboldtstr. 10 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-2728","authenticated-orcid":false,"given":"Philipp","family":"Buday","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-Universit\u00e4t Institut f\u00fcr Anorganische und Analytische Chemie  Humboldtstr. 8 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-1006","authenticated-orcid":false,"given":"Wolfgang","family":"Weigand","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-Universit\u00e4t Institut f\u00fcr Anorganische und Analytische Chemie  Humboldtstr. 8 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4660-1691","authenticated-orcid":false,"given":"Phil","family":"Liebing","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-Universit\u00e4t Institut f\u00fcr Anorganische und Analytische Chemie  Humboldtstr. 8 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-1422","authenticated-orcid":false,"given":"Hans\u2010Dieter","family":"Arndt","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-Universit\u00e4t Institut f\u00fcr Organische Chemie und Makromolekulare Chemie  Humboldtstr. 10 07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08300"},{"key":"e_1_2_3_2_1","unstructured":"\u00a0"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2057"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00156-4"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053764635"},{"key":"e_1_2_3_6_1","unstructured":"\u00a0"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.60.2.439-471.1996"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.061505.175355"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08992"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201803444"},{"key":"e_1_2_3_11_1","unstructured":"\u00a0"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6MT00208K"},{"key":"e_1_2_3_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702879104"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja804747d"},{"key":"e_1_2_3_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi051815t"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112921109"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00058-15"},{"key":"e_1_2_3_18_1","unstructured":"\u00a0"},{"key":"e_1_2_3_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098322"},{"key":"e_1_2_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi047367r"},{"key":"e_1_2_3_21_1","unstructured":"\u00a0"},{"key":"e_1_2_3_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap9437"},{"key":"e_1_2_3_23_2","first-page":"12","volume":"83","author":"Gu W. Y.","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"key":"e_1_2_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2123566119"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85226"},{"key":"e_1_2_3_26_1","unstructured":"\u00a0"},{"key":"e_1_2_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.19264490116"},{"key":"e_1_2_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00514724"},{"key":"e_1_2_3_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01068a030"},{"key":"e_1_2_3_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo9803380"},{"key":"e_1_2_3_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo3021192"},{"key":"e_1_2_3_32_1","unstructured":"\u00a0"},{"key":"e_1_2_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.188301602235"},{"key":"e_1_2_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/cber.18840170215"},{"key":"e_1_2_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18932750102"},{"key":"e_1_2_3_36_1","unstructured":"\u00a0"},{"key":"e_1_2_3_37_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-1979-28634"},{"key":"e_1_2_3_38_2","doi-asserted-by":"publisher","DOI":"10.3987\/R-1987-04-1077"},{"key":"e_1_2_3_39_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0627904"},{"key":"e_1_2_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201200085"},{"key":"e_1_2_3_41_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA15590D"},{"key":"e_1_2_3_42_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA00301J"},{"key":"e_1_2_3_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600639"},{"key":"e_1_2_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2011.03.070"},{"key":"e_1_2_3_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol701599v"},{"key":"e_1_2_3_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol303324a"},{"key":"e_1_2_3_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo901565n"},{"key":"e_1_2_3_48_1","unstructured":"\u00a0"},{"key":"e_1_2_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198400711"},{"key":"e_1_2_3_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.198404361"},{"key":"e_1_2_3_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CC14773K"},{"key":"e_1_2_3_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0703505"},{"key":"e_1_2_3_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01544"},{"key":"e_1_2_3_54_1","unstructured":"\u00a0"},{"key":"e_1_2_3_55_2","doi-asserted-by":"publisher","DOI":"10.1039\/j39660001191"},{"key":"e_1_2_3_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00219a008"},{"key":"e_1_2_3_57_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja00978a049"},{"key":"e_1_2_3_58_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo00200a058"},{"key":"e_1_2_3_59_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01095a033"},{"key":"e_1_2_3_60_1","unstructured":"\u00a0"},{"key":"e_1_2_3_61_2","doi-asserted-by":"publisher","DOI":"10.1021\/ol303124r"},{"key":"e_1_2_3_62_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC05194B"},{"key":"e_1_2_3_63_2","first-page":"18","volume":"2004","author":"Begue J.-P.","year":"2004","journal-title":"Synlett"},{"key":"e_1_2_3_64_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-983902"},{"key":"e_1_2_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-017-0088"},{"key":"e_1_2_3_66_1","doi-asserted-by":"publisher","DOI":"10.6028\/jres.068A.056"},{"key":"e_1_2_3_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic101965j"},{"key":"e_1_2_3_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201706035"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202304901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T02:32:47Z","timestamp":1698201167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202304901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,12]]},"references-count":68,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2023,10,16]]}},"alternative-id":["10.1002\/anie.202304901"],"URL":"https:\/\/doi.org\/10.1002\/anie.202304901","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.26434\/chemrxiv-2023-9rqvp","asserted-by":"object"}]},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,12]]},"assertion":[{"value":"2023-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202304901"}}