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Other key points in our synthetic strategy encompass a Diels\u2013Alder reaction to construct the middle six\u2010membered ring of sculponin\u2005U, and an intramolecular radical cyclization induced by iron\u2010catalyzed hydrogen atom transfer to close the western cyclohexane ring. Successful preparation of the enantiopure silyl enolate as the PET precursor enables the asymmetric total synthesis of sculponin\u2005U, opening a new avenue for divergent syntheses of structurally related C\u201020\u2010oxygenated kaurane congeners and pharmaceutical derivatives thereof.<\/jats:p>","DOI":"10.1002\/anie.202305516","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T07:34:40Z","timestamp":1684395280000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Total Synthesis of Sculponin\u2005U through a Photoinduced Radical Cascade Cyclization"],"prefix":"10.1002","volume":"62","author":[{"given":"Wei","family":"Cao","sequence":"first","affiliation":[{"name":"College of Chemistry Sichuan University  29 Wangjiang Rd. 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