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Medications or surgery have been considered as effective protocols to treat IHD for decades. Yet the reperfusion of the blood flow frequently leads to the generation of excessive reactive oxygen species (ROS), causing prominent and irreversible damage to the cardiomyocytes. In the present work, tannic acid\u2010assembled tetravalent cerium (TA\u2212Ce) nanocatalysts with appealing cardiomyocyte\u2010targeting and antioxidation capability have been synthesized and applied for the effective and biocompatible ischemia\/reperfusion injury therapeutics. TA\u2212Ce nanocatalysts could effectively rescue the cardiomyocytes from oxidative stress induced by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    challenge as well as oxygen\u2010glucose deprivation in vitro. In the murine ischemia\/reperfusion model, cardiac accumulation and intracellular ROS scavenging could be achieved against the pathology, substantially reducing the myocardial infarct area and recovering heart functionality. This work illuminates the design of nanocatalytic metal complexes and their therapeutic prospects in ischemic heart diseases with high effectiveness and biocompatibility, paving the way for the clinical translation from bench to bedside.\n                  <\/jats:p>","DOI":"10.1002\/anie.202305576","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T12:05:35Z","timestamp":1687867535000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Myocardial\u2010Targeting Tannic Cerium Nanocatalyst Attenuates Ischemia\/Reperfusion Injury"],"prefix":"10.1002","volume":"62","author":[{"given":"Liping","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Institute of Ceramics Chinese Academy of Sciences Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease Chinese Academy of Medical Sciences (2021RU012)  Shanghai 200050 P. R. China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 100049 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Shanghai Tenth People's Hospital Shanghai Frontiers Science Center of Nanocatalytic Medicine School of Medicine Tongji University  Shanghai 200072 P. R. 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