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This protocol gives access to chiral trifluoromethylated propargyl ethers and anilines, which are valuable building blocks in synthetic and medicinal chemistry. The reaction proceeds with high enantioselectivity and yield with different nucleophiles such as primary, secondary and tertiary alcohols, as well as both electron\u2010rich and electron\u2010poor anilines. Aryl\u2010, alkyl\u2010 and silyl\u2010substituted alkynes can be successfully introduced as electrophiles. In case of chiral substrates, high catalyst control was observed, leading to good diastereoselectivity.\n                  <\/jats:p>","DOI":"10.1002\/anie.202305776","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T13:53:45Z","timestamp":1685627625000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Copper (I)\u2010BOX Catalyzed Asymmetric 3\u2010Component Reaction for the Synthesis of Trifluoromethylated Propargylic Ethers and Anilines**"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-4469","authenticated-orcid":false,"given":"Nieves P.","family":"Ramirez","sequence":"first","affiliation":[{"name":"Laboratory of Catalysis and Organic Synthesis, Institute of Chemical Sciences and Engineering Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (LCSO-ISIC-EPFL) and National Centre of Competence and Research (NCCR Catalysis)  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-914X","authenticated-orcid":false,"given":"Jerome","family":"Waser","sequence":"additional","affiliation":[{"name":"Laboratory of Catalysis and Organic Synthesis, Institute of Chemical Sciences and Engineering Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (LCSO-ISIC-EPFL) and National Centre of Competence and Research (NCCR Catalysis)  1015 Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"e_1_2_3_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/B711844A"},{"key":"e_1_2_3_2_1","unstructured":"\u00a0"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781444305371"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131943"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm800219f"},{"key":"e_1_2_3_6_2","volume-title":"Fluorine in Pharmaceutical and Medicinal Chemistry: From Biophysical Aspects to Clinical Applications","author":"Swallow S.","year":"2012"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00258"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00830"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00632"},{"key":"e_1_2_3_10_1","unstructured":"Selected reviews for propargylic alcohols\/ethers:"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1290158"},{"key":"e_1_2_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202002141"},{"key":"e_1_2_3_13_1","unstructured":"Selected reviews for propargylic amines:"},{"key":"e_1_2_3_14_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.13.61"},{"key":"e_1_2_3_15_2","first-page":"2704","author":"Irfana J.","year":"2019","journal-title":"Eur. 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