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However, most chemiluminescent nanoprobes suffer from shallow imaging depths and slow clearance from living bodies, which impede their use in clinical settings. We herein report size\u2010transformable nanoreporters (ADN1 and ADN2) that could be activated at disease site by superoxide anion (O\n                    <jats:sub>2<\/jats:sub>\n                    \u22c5\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) to trigger nanostructure disassembly into renal excretable fluorescent fragments as well as chemiluminescence turn\u2010on for crosstalk\u2010free duplex chemo\u2010fluorescence imaging and in vitro urinalysis. In peritonitis mouse model, we demonstrate that the representative nanoreporter ADN1 spontaneously accumulates at the disrupted peritoneum and is cleaved by upregulated O\n                    <jats:sub>2<\/jats:sub>\n                    \u22c5\n                    <jats:sup>\u2212<\/jats:sup>\n                    to initiate depolymerization and result in red chemiluminescence at 620\u2005nm, enabling sensitive detection of peritonitis at least 19\u2005h earlier than gold standard histological assays. Additionally, the incorporation of a near\u2010infrared (NIR) dye into ADN1 results in ADN2 exhibiting intense and red\u2010shifted chemiluminescence at \u2248800\u2005nm, which permits early detection of deeply seated diseases such as drug\u2010induced hepatotoxicity. This study thus showcases a modular design strategy that is not only applicable to developing versatile chemiluminescent nanoprobes with switchable pharmacokinetics for early disease diagnosis, but also promising for future clinical translations.\n                  <\/jats:p>","DOI":"10.1002\/anie.202305812","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T23:11:00Z","timestamp":1685574660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Size\u2010Transformable Superoxide\u2010Triggered Nanoreporters for Crosstalk\u2010Free Dual Fluorescence\/Chemiluminescence Imaging and Urinalysis in Living Mice"],"prefix":"10.1002","volume":"62","author":[{"given":"Bankang","family":"Ruan","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Sun Yat-sen University  510006 Guangzhou China"},{"name":"National-Local Joint Engineering Laboratory of Druggability and 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