{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:59:25Z","timestamp":1790369965954,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"39","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute renal allograft rejection (ARAR) after kidney transplantation associated with reduced graft survival and eventual graft failure is poorly diagnosed in hospitals. Here, we report the development of\n                    <jats:styled-content>A<\/jats:styled-content>\n                    rtificial bio\n                    <jats:styled-content>M<\/jats:styled-content>\n                    arker\n                    <jats:styled-content>Pro<\/jats:styled-content>\n                    bes (AMPros) for sensitive urinalysis of ARAR in murine models. AMPros spontaneously go to the kidneys after systemic administration, specifically react with the prodromal immune biomarkers to activate their near\u2010infrared fluorescence signals to report cell\u2010mediated rejection, and efficiently undergo renal excretion into urine. Thus, AMPros enable convenient optical urinalysis that detects ARAR prior to histological manifestation of rejection, which is also earlier than current diagnostic methods measuring proinflammatory cytokines and peripheral blood lymphocyte mRNAs. Due to the high kidney specificity, AMPros\u2010based urinalysis discriminates allograft rejection against other non\u2010alloimmune specific diseases, which is unattainable by measurement of serological biomarkers. Such a noninvasive and sensitive urine test holds great promise in continuous monitoring of renal allograft conditions at low resource settings for timely clinical interventions.\n                  <\/jats:p>","DOI":"10.1002\/anie.202306539","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T04:40:41Z","timestamp":1689050441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Artificial Urinary Biomarkers for Early Diagnosis of Acute Renal Allograft Rejection"],"prefix":"10.1002","volume":"62","author":[{"given":"Penghui","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University  70 Nanyang Drive 637457 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rending","family":"Wang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center the First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Kidney Disease Prevention and Control Technology  Zhejiang Province P. R. China"},{"name":"Organ Donation and Coordination Office the First Affiliated Hospital School of Medicine Zhejiang University  Hangzhou 310003 Zhejiang Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"He","sequence":"additional","affiliation":[{"name":"School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University  70 Nanyang Drive 637457 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengpeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Kidney Disease Center the First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Kidney Disease Prevention and Control Technology  Zhejiang Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center the First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Kidney Disease Prevention and Control Technology  Zhejiang Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center the First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Kidney Disease Prevention and Control Technology  Zhejiang Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center the First Affiliated Hospital College of Medicine Zhejiang University Key Laboratory of Kidney Disease Prevention and Control Technology  Zhejiang Province P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8064-6009","authenticated-orcid":false,"given":"Kanyi","family":"Pu","sequence":"additional","affiliation":[{"name":"School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University  70 Nanyang Drive 637457 Singapore Singapore"},{"name":"Lee Kong Chian School of Medicine Nanyang Technological University  59 Nanyang Drive Singapore, Singapore 636921 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00425-3"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0902927"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2015.06.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.10.119"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.213"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.281"},{"key":"e_1_2_7_7_1","first-page":"106","volume":"10","author":"Erpicum P.","year":"2017","journal-title":"Clin. Kidney J."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5303284"},{"key":"e_1_2_7_9_1","unstructured":"\u00a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-018-0038-3"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201905899"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-021-00440-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-021-00328-6"},{"key":"e_1_2_7_14_1","unstructured":"\u00a0"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-021-00804-0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15035a"},{"key":"e_1_2_7_17_1","unstructured":"\u00a0"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-019-0378-4"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201910137"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002733"},{"key":"e_1_2_7_21_1","unstructured":"\u00a0"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00335"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg010"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.731144"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V10112446"},{"key":"e_1_2_7_26_1","first-page":"96","volume":"52","author":"Lou Y.-H.","year":"2004","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2454"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200005270-00031"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.39"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra033540"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c00659"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202306539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202306539","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202306539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T10:00:46Z","timestamp":1787392846000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202306539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,24]]},"references-count":31,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2023,9,25]]}},"alternative-id":["10.1002\/anie.202306539"],"URL":"https:\/\/doi.org\/10.1002\/anie.202306539","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,24]]},"assertion":[{"value":"2023-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202306539"}}