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The short half\u2010life and short diffusion distance of reactive oxygen species (ROS) also limit the antibacterial efficiency of PDT. Herein, we designed a targeting singlet oxygen delivery system, CARG\u2010Py, for irradiation\u2010free and oxygen\u2010free PDT. This system was converted to the \u201csinglet oxygen battery\u201d CARG\u2010\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and released singlet oxygen without external irradiation or oxygen. CARG\u2010\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    is composed of pyridones coupled to a targeting peptide that improves the utilization of singlet oxygen in deep multidrug\u2010resistant bacterial infections. CARG\u2010\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    was shown to damage DNA, protein, and membranes by increasing the level of reactive oxygen inside bacteria; the attacking of multiple biomolecular sites caused the death of methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA). An\n                    <jats:italic>in vivo<\/jats:italic>\n                    study in a MRSA\u2010infected mouse model of pneumonia demonstrated the potential of CARG\u2010\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    for the efficient treatment of deep infections. This work provides a new strategy to improve traditional PDT for irradiation\u2010 and oxygen\u2010free treatment of deep infections while improving convenience of PDT.\n                  <\/jats:p>","DOI":"10.1002\/anie.202306803","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T08:00:35Z","timestamp":1689580835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["A Targeting Singlet Oxygen Battery for Multidrug\u2010Resistant Bacterial Deep\u2010Tissue Infections"],"prefix":"10.1002","volume":"62","author":[{"given":"Yiwen","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education) Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 100029 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