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Here we report such a foldamer architecture based on alternating pyridine\u2010diketopiperazine linkers. Epimerization is conveniently prevented through a copper\u2010catalyzed coupling protocol. The compounds\u2019 native unswitched conformation is first discovered in the solid and solution state. The foldamers can be solubilized in DMSO and pH\u20059.5 buffer, retaining conformational control to a large degree. Lastly, dynamic switching is demonstrated through treatment with acid, leading to behaviour we describe as stimulus\u2010responsive sidechain reconfiguration.<\/jats:p>","DOI":"10.1002\/anie.202307180","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T02:22:04Z","timestamp":1688696524000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Non\u2010Covalent Interactions Enforce Conformation in Switchable and Water\u2010Soluble Diketopiperazine\u2010Pyridine Foldamers"],"prefix":"10.1002","volume":"62","author":[{"given":"Sinead","family":"McCann","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Queen's University Belfast  David Keir Building, Stranmillis Road Belfast BT9 5AG UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-4048","authenticated-orcid":false,"given":"William 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