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Herein, we report a method for ruthenium\u2010catalyzed activation of nonpolar C\u2212C bonds of pro\u2010aromatic compounds by means of \u03c0\u2010coordination\u2010enabled aromatization. This method was effective for cleavage of C\u2212C(alkyl) and C\u2212C(aryl) bonds and for ring\u2010opening of spirocyclic compounds, providing an array of benzene\u2010ring\u2010containing products. The isolation of a methyl ruthenium complex intermediate supports a mechanism involving ruthenium\u2010mediated C\u2212C bond cleavage.<\/jats:p>","DOI":"10.1002\/anie.202307285","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T16:41:03Z","timestamp":1687970463000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ruthenium\u2010Catalyzed Activation of Nonpolar C\u2212C Bonds via \u03c0\u2010Coordination\u2010Enabled Aromatization"],"prefix":"10.1002","volume":"62","author":[{"given":"Lun","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of Chemistry School of Science and Research Center for Industries of the Future Westlake University  600 Dunyu Road Hangzhou 310030 Zhejiang Province 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