{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:10:00Z","timestamp":1791274200398,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1500402"],"award-info":[{"award-number":["2021YFA1500402"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20401, 22161142001"],"award-info":[{"award-number":["U22A20401, 22161142001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of heterogeneous asymmetric catalysts has attracted increasing interest in synthetic chemistry but mostly relies on the immobilization of homogeneous chiral catalysts. Herein, a series of chiral metal\u2013organic frameworks (MOFs) have been fabricated by anchoring similar chiral hydroxylated molecules (catalytically inactive) with different lengths onto Zr\u2010oxo clusters in achiral PCN\u2010222(Cu). The resulting chiral MOFs exhibit regulated enantioselectivity up to 83\u2009%\u2009<jats:italic>ee<\/jats:italic> in the asymmetric ring\u2010opening of cyclohexene oxide. The chiral molecules furnished onto the catalytic Lewis sites in the MOF create multilevel microenvironment, including the hydrogen interaction between the substrate and the chiral \u2212OH group, the steric hindrance endowed by the benzene ring on the chiral molecules, and the proximity between the catalytic sites and chiral molecules confined in the MOF pores, which play crucial roles and synergistically promote chiral catalysis. This work nicely achieves heterogeneous enantioselective catalysis by chiral microenvironment modulation around Lewis acid sites.<\/jats:p>","DOI":"10.1002\/anie.202308089","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T11:20:54Z","timestamp":1691493654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Turning on Asymmetric Catalysis of Achiral Metal\u2010Organic Frameworks by Imparting Chiral Microenvironment"],"prefix":"10.1002","volume":"62","author":[{"given":"Ge","family":"Yang","sequence":"first","affiliation":[{"name":"Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China  230026 Hefei Anhui P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Shi","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  230026 Hefei Anhui P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyang","family":"Qian","sequence":"additional","affiliation":[{"name":"Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China  230026 Hefei Anhui P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of China  230026 Hefei Anhui P.\u2005R. China"},{"name":"Department of Chemistry Fudan University  200433 Shanghai P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Meng","sequence":"additional","affiliation":[{"name":"Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China  230026 Hefei Anhui P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-7977","authenticated-orcid":false,"given":"Hai\u2010Long","family":"Jiang","sequence":"additional","affiliation":[{"name":"Hefei National Research Center for Physical Sciences at the Microscale Department of Chemistry University of Science and Technology of China  230026 Hefei Anhui P.\u2005R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/9781119736424"},{"key":"e_1_2_7_3_1","unstructured":"\u00a0"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083622"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07367"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00074"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00615B"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00515"},{"key":"e_1_2_7_9_1","unstructured":"\u00a0"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07066"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06688"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202006383"},{"key":"e_1_2_7_13_1","unstructured":"\u00a0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202000875"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c08109"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112797"},{"key":"e_1_2_7_17_1","unstructured":"\u00a0"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230444"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00328"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-022-01346-7"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.enchem.2022.100080"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00759-7"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/aenm.202003970"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213479"},{"key":"e_1_2_7_25_1","unstructured":"\u00a0"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201800702"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00968K"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b02228"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00250A"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00460"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.1c00009"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202206706"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200180"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.11.023"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1872-2067(22)64193-7"},{"key":"e_1_2_7_36_1","unstructured":"\u00a0"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00416-8"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12117"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.10.031"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic502380q"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.738"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c02529"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b11221"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202213399"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.628"},{"key":"e_1_2_7_46_1","unstructured":"\u00a0"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.7b02854"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja901440g"},{"key":"e_1_2_7_49_1","unstructured":"\u00a0"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085515"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00253J"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2020.213600"},{"key":"e_1_2_7_53_1","unstructured":"\u00a0"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0354-z"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00869"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c07066"},{"key":"e_1_2_7_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33987-2"},{"key":"e_1_2_7_58_1","unstructured":"\u00a0"},{"key":"e_1_2_7_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013926"},{"key":"e_1_2_7_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11355-x"},{"key":"e_1_2_7_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202104111"},{"key":"e_1_2_7_62_1","unstructured":"\u00a0"},{"key":"e_1_2_7_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201204475"},{"key":"e_1_2_7_64_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic300825s"},{"key":"e_1_2_7_65_2","doi-asserted-by":"publisher","DOI":"10.1021\/ic301923x"},{"key":"e_1_2_7_66_1","unstructured":"\u00a0"},{"key":"e_1_2_7_67_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja408959g"},{"key":"e_1_2_7_68_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c05032"},{"key":"e_1_2_7_69_1","unstructured":"\u00a0"},{"key":"e_1_2_7_70_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00428"},{"key":"e_1_2_7_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201001222"},{"key":"e_1_2_7_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcat.2018.11.038"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.9b00960"},{"key":"e_1_2_7_74_1","unstructured":"\u00a0"},{"key":"e_1_2_7_75_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c02955"},{"key":"e_1_2_7_76_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6DT04745A"},{"key":"e_1_2_7_77_1","unstructured":"\u00a0"},{"key":"e_1_2_7_78_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.22885"},{"key":"e_1_2_7_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.26812"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202308089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T16:56:26Z","timestamp":1694710586000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202308089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":79,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2023,9,18]]}},"alternative-id":["10.1002\/anie.202308089"],"URL":"https:\/\/doi.org\/10.1002\/anie.202308089","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]},"assertion":[{"value":"2023-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202308089"}}