{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:52:16Z","timestamp":1790959936776,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM124791"],"award-info":[{"award-number":["R35 GM124791"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","award":["Lilly Grantee Award"],"award-info":[{"award-number":["Lilly Grantee Award"]}],"id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2023,10,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nickel PyBox catalysts promote nucleophilic cyclopropanation reactions using CH\n                    <jats:sub>2<\/jats:sub>\n                    Cl\n                    <jats:sub>2<\/jats:sub>\n                    as a methylene source and Mn as a stoichiometric reductant. The substrate scope includes a broad range of alkenes bearing electron\u2010withdrawing substituents, including esters, amides, ketones, nitriles, sulfones, phosphonate esters, trifluoromethyl groups, and electron\u2010deficient arenes. Enantioselective cyclopropanations of \u03b1,\u03b2\u2010unsaturated esters have been developed using chiral PyBox ligands. Mechanistic studies suggest the intermediacy of a (PyBox)Ni=CH\n                    <jats:sub>2<\/jats:sub>\n                    species, which adds to the alkene by a stepwise [2+2]\u2010cycloaddition\/C\u2212C reductive elimination mechanism. DFT models provide a rationale for the nucleophilic character of the nickel carbene and the sense of enantioinduction.\n                  <\/jats:p>","DOI":"10.1002\/anie.202308913","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T22:39:03Z","timestamp":1693780743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Nucleophilic Carbenes Derived from Dichloromethane"],"prefix":"10.1002","volume":"62","author":[{"given":"Mingxin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry Purdue University  560 Oval Dr. West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Chemistry Purdue University  560 Oval Dr. West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-915X","authenticated-orcid":false,"given":"Christopher","family":"Uyeda","sequence":"additional","affiliation":[{"name":"Department of Chemistry Purdue University  560 Oval Dr. West Lafayette IN 47907 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01552a080"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja01525a036"},{"key":"e_1_2_7_4_2","first-page":"1","volume":"58","author":"Charette A. 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